Staphylococcinum nosode may be used as a Homeopathic or used simply as a micro-nutritional. Homeopathic potencies accredit their strength and efficacy to the electromagnetic signatures of the original substrate; these are scientifically created dilutions and succussions of medicines such that generally not even a molecule of the original substrate or medicine is present in the medicine.

As a Homeopathic or used simply as a micro-nutritional, Staphylococcinum nosode has demonstrated effectiveness against the following symptomology: "isotherapeutic to etiological microbia element present in many cases of acne; Disease where the staphylococcus is the chief factor, as in acne..." (Boericke)