Staphisagria may be used as a Homeopathic or used simply as a micro-nutritional (botanical). Homeopathic potencies accredit their strength and efficacy to the electromagnetic signatures of the original substrate; these are scientifically created dilutions and succussions of medicines such that generally not even a molecule of the original substrate or medicine is present in the medicine.

As a Homeopathic or used simply as a micro-nutritional, Staphisagria has demonstrated effectiveness against the following symptomology: nymphomania with extreme sensitiveness to mental and physical impressions; the mind dwells too much on sexual subjects; -painful sensitiveness of genital organs; -sufferings after coition in newly married women; -inflammation of ovaries with burning, stinging and pressing-drawing; -very sharp shooting pains in ovary which is exceedingly sensitive to pressure; -flow of blood from genitals a long time after menopause has passed; -spasmodic pains in vulva and vagina; -amenorrhea from chagrin with indignation; -menses irregular, late, profuse; sometimes wanting (missing); first of pale blood, then dark and clotted; occasionally spasmodic uterine contractions (Clarke).Also effective as a homeopathic medicine for mechanical injuries from sharp-cutting instruments: clean, incised wounds; -discharges from wound of a greenish color (Lilienthal)

Staphisagria is also said to have the follow uses: -"Suits clean cut wounds and symptoms traceable to surgical operations, especially about the abdomen when colic is a troublesome condition following. Also after lithotomy, wounds from glass, and so on, where the pains are excruciating, rending and tearing, causing great agony. It is an excellent remedy to use following operations for lacerated cervix." (Dewey) -nervous affections with marked irritability; acts on teeth and alveolar periosteum: pain and nervousness after extraction of teeth; -lacerated or incised wounds of cornea; -sphincters lacerated or stretched (Boericke)