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Silymarin (Silybum Marianum, Milk Thistle)
Milk Thistle, also known as Silymarin,
is an ancient remedy where in 1000 A.D., Pliny is recorded to
have used it as a nutritional remedy to build the strength of
his patients. In the 16th century, a physician actually used
the crushed seeds of Milk Thistles for liver ailments, a practice
which continues in Europe today in the treatment of chronic
liver problems and general detoxification. Silymarin extract
and its major components have been shown in animal and human
studies to exert a hepatoprotectant effect.
The compounds or active phytomedicinals found in Milk Thistle
appear to reduce liver damage caused by biological and chemical
insult, and thus can protect the liver from poisons and pollutants,
such as alcohol, carbon tetrachloride, acetaminophen overdose
and Deathcap mushroom (Amanita phalloides) which causes death
within a day. Silymarin has been demonstrated to be effective
in treating a number of chronic liver problems including liver
inflammation, chronic cirrhosis of the liver, toxic metabolic
liver disease, acute viral hepatitis, chronic hepatitis, fatty
degeneration of the liver and other diseases of unknown etiology.
Positive effects have been observed in alcohol-induced and iatrogenic
(drug-induced) forms of cirrhosis.
The active phytomedicinals include the family of silymarin (a
number of flavonoids silmarin, silybin, sildianin, and silychristin).
Silymarin appears to act upon cell membranes, stabilizing them
while encouraging the regenerative of cells destroyed during
the normal detoxifying process. The mechanism of action of silymarin
involves altering the membranes of hepatic cells to inhibit
passage of toxins and increasing cellular regeneration by stimulating
protein synthesis. Recent research has indicated that silymarin
helps to protect against depletion of the antioxidant amino
acid L-Glutathione in liver cells. Milk thistle is also used
for the increased production of bile, which acts to emulsify
fats, and thus aids in digestion of fats and useful for psoriasis.
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