Scrophularia nodosum may be used as a Homeopathic or used simply as a micro-nutritional (botanical). Homeopathic potencies accredit their strength and efficacy to the electromagnetic signatures of the original substrate; these are scientifically created dilutions and succussions of medicines such that generally not even a molecule of the original substrate or medicine is present in the medicine.

As a Homeopathic or used simply as a micro-nutritional, Scrophularia nodosum has demonstrated effectiveness against the following symptomology: "Breast tumors; tubercular eye problems; eczema; supporting remedy in neoplasm phases." (Reckeweg) -"Of service in diseases of the skin, eczema, crusta lactea, eruptions of a vesicular character, pruritus vaginae, herpetic ulceration and scrofulous (ie, glandular) swellings...and indications of perverted nutrition." (Blackwood)

-Scrophularia nodosum is also said to be "A powerful medicine whenever enlarged glands are present. Hodgkin's disease. A valuable skin remedy. Has a specific affinity for the breast: very useful in dissipation of breast tumors. Nodosities of the breasts. Lupoid ulceration." (Boericke) -clinical conditions: appendicitis; breast, tumors of; eyes, scrofulous affections of; glands, enlarged; liver, pains in; pemphigus; rheumatism; sigmoid flexure, pains in (Clarke).