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Resveratrol (Protykin)

Resveratrol is a phytoalexin, an all natural compound found in abundance in the skin of red grapes and most abundantly in the root of Polygonum cuspidatum (from which Protykin is made: 20% trans-Resveratrol, 10% Emodin), a tradtitional chinese herb also known as Hu-chang, as well as 70 other plant species. Its now believed that the benefits of red wine (and ordinary 100% pure grape juice!) are derived, amongst other ingredients, from their resveratrol content. White wine (or white grape juice) is not so beneficial as the skins of the grapes are discarded upon first pressings, and thus very little resveratrol is present. Resveratrol can also be found in other foods (such as peanuts, mulberries and 70 other plant species), but its not as abundant as it is in the red grape skin.Phytoalexins are a group of compounds that are normally produced during times of environmental stress or pathogenic attack. Resveratrol, which can be extracted from the skin of red grapes, is reported to have cancer-fighting abilities in assays representing three major stages of carcinogenesis, as reported in Science (Cancer Chemopreventative Activity of Resveratrol, A Natural Product Derived From Grapes, Jang, M., et al, Vol 275, pg 218-219, 1997).

These researchers demonstrated the power of resveratrol (3,5,4'-trihyroxy-trans-stilbene, or C14H12O3) where resveratrol inhibits cellular events associated with tumor initiation, promotion and progression. As reported, it acts as an anti-inflammatory due to its ability to inhibit the cycloxygenase (COX) and hydroperoxidase acitivity (antipromotion acitivity). On its own, COX can stimulate tumor cell growth, suppress immune surveillance, and activate carcinogen forms that damage genetic material. Resveratrol also induced human promyelocytic leukemia cell differentiation (antiprogressive activity). Resveratrol also acts as an antioxidant, antimutagen, inducing quinone reductase activity, which detoxifies carcinogens. In animal studies, resveratrol inhibited tumor and lesion formation in the mammary glands and skin of mice. It is also thought that resveratrol could play a part in the prevention of heart disease because it also inhibits platelet aggregation and coagulation, alters eicosanoid synthesis and modulates lipoprotein metabolism.


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