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Pyruvates (Pyruvaic acid, Potassium Pyruvate, Magn)
Pyruvates are molecules involved
in the Krebs' cycle wherein carbohydrate metabolism is enacted.
The breakdown of carbohydrates into immediate (ATP) and stored
energy (as glycogen and fat) is critically important for the
body's management of energy needs and uses. Unfortunately for
most mammals including man, fats by themselves cannot be directly
converted to glucose. Pyruvates are critically important to
help in the process of gluconeogenesis, wherein the mobilization
of fats stores and their respective oxidation (breakdown) can
take place (occurring during starvation or periods of exercise).
Pyruvates can both suppress and stimulate acetyl CoA, which
comes from the oxidation of fatty acids. It is from acetyl CoA
via pyruvate activity that glucose is metabolized. Without sufficient
pyruvates, muscle proteins must be biodegraded to maintain glucose
homeostasis in the starving/fasting state, thereby causing wasting
of the skeletal muscles. Thus an increase in dietary pyruvates
may be able to hasten fatty acid burn, although generally exercise
makes this more probable and efficient. Pyruvates can be metabolized
from free form amino acids through the process of transamination
in the liver, and pyruvates can then be converted into glucose
via gluconeogenesis.
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