Pulsatilla nigricans may be used as a Homeopathic or used simply as a micro-nutritional (botanical). Homeopathic potencies accredit their strength and efficacy to the electromagnetic signatures of the original substrate; these are scientifically created dilutions and succussions of medicines such that generally not even a molecule of the original substrate or medicine is present in the medicine.

As a Homeopathic or used simply as a micro-nutritional, Pulsatilla nigricans has demonstrated effectiveness against the following symptomology: "Should be remembered in delayed and scanty menstruation. The patient is constantly chilly; there is bearing down pressure in the abdomen and sacral region, with faintness in the stomach; she is worse in a warm room and better in open air. In dysmenorrhea when the pains are violent and cause her to toss in all directions, the blood is thick and black or pale and watery, she feels better in the cool air. Also amenorrhea in those who are pale, anemic, chilly, of a tearful, yielding disposition; it frequently relieves a thick, white albuminous leucorrhea..." (Blackwood).

As a Homeopathic or used simply as a micro-nutritional, Pulsatilla nigricans has demonstrated effectiveness against the following digestive symptomology: averse to fat food, warm food and drink; -eructations with taste of food remains a long time; after ices, fruits, pastry; dislikes butter; -bitter taste, diminished taste of all food; flatulence; heartburn; dyspepsia with great tightness after meal, must loosen clothing; pain in stomach an hour after eating; -vomiting of food eaten long before; waterbrash with foul taste in the morning; weight as from a stone in the stomach especially in morning on awakening; -all-gone sensation in stomach (especially in tea drinkers) -foods which disagree/ill effects of: bread-butter-warm or hot drinks-fats-warm food-meat-pastry-pork-sausage (Boericke).Also as a Homeopathic or used simply as a micro-nutritional, it has demonstrated effectiveness against the following PMS symptomology: before menses: weeping, sadness, pale face, migraines, thick white leucorrhea; -irregular, delayed or scanty menses, flowing in fits and starts; -shivering coldness of body, sadness, melancholy, weeping mood, trembling of feet; -discharge thick, clotted, viscous or pale and watery, changeable with erratic pains, flying from one place to another; -during flow, fainting, nausea, vomiting, sour slimy taste, difficulty of breathing when in a warm room, pressure in abdomen and small of back as from a stone; -menses flow more while walking about... (Lilienthal).