Podophyllum peltatum may be used as a Homeopathic or used simply as a micro-nutritional (botanical). Homeopathic potencies accredit their strength and efficacy to the electromagnetic signatures of the original substrate; these are scientifically created dilutions and succussions of medicines such that generally not even a molecule of the original substrate or medicine is present in the medicine.

As a Homeopathic or used simply as a micro-nutritional, Podophyllum peltatum has demonstrated effectiveness against the following symptomology: "It affects chiefly the duodenum, small intestines, liver and rectum... for worms. Torpidity of the liver; portal engorgement with tendency to hemorrhoids, hypogastric pains, fullness of superficial veins, jaundice." -sensation of sinking or weakness in abdomen; can lie comfortably only on stomach; liver region painful, better rubbing the part; -rumbling and shifting of flatus in ascending colon; -diarrhea of long standing; -painless early morning diarrhea; green, watery, fetid, profuse, gushing; -prolapse of rectum before or with stool; -constipation alternating with diarrhea; -constipation: clay-colored, hard, dry, difficult (Boericke).