Natrum sulphuricum may be used as a Homeopathic or used simply as a micro-nutritional (tissue salt). Homeopathic potencies accredit their strength and efficacy to the electromagnetic signatures of the original substrate; these are scientifically created dilutions and succussions of medicines such that generally not even a molecule of the original substrate or medicine is present in the medicine.

As a Homeopathic or used simply as a micro-nutritional, Natrum sulphuricum has demonstrated effectiveness against the following symptomology: "Dr. Hinsdale reports good results with this remedy: it has polyuria, intense itching of the skin-especially the upper surfaces of the thighs. It is the 'Tissue Remedy' of diabetes." (Dewey) -urine loaded with bile; brick-dust sediment; excessive secretion of urine; diabetes (Boericke).