Ignatia amara may be used as a Homeopathic or used simply as a micro-nutritional (botanical). Homeopathic potencies accredit their strength and efficacy to the electromagnetic signatures of the original substrate; these are scientifically created dilutions and succussions of medicines such that generally not even a molecule of the original substrate or medicine is present in the medicine.

As a Homeopathic or used simply as a micro-nutritional, Ignatia amara has demonstrated effectiveness against the following symptomology: intense pressing headache often only over a small spot, going to the eye which feels as if pressed out, or to the root of the nose; -at height of the paroxysm becomes restless and chilly, sees fiery zigzags when looking out of the line of vision, finally getting relief from profuse flow of colorless urine; -periodical headaches returning every two weeks; -pressing frontal headache over the glabella, must bend head forward, followed by inclination to vomit, worse after eating, also worse in the evening when lying down or in the morning when getting up; -migraine brought on by mental labor or by any work that is irksome or more severe than usual; by emotions; by any strong odor; -aggravated from coffee, tobacco or alcohol, even when coming into a room where another is smoking, and often ending with vomiting; -tendency to be startled, fitful mood, taciturn, sad (Lilienthal).

As a Homeopathic or used simply as a micro-nutritional, Ignatia amara has also demonstrated effectiveness against the following depressive symptomology: "Most cases of melancholia at some period of their treatment require Ignatia...The patient is melancholic, given to sighing, with a tendency to weep...hides the grief, is introspective, changeable and silent...a remedy full of disappointments, and jealousy...most suitable to complaints arising from fear, grief, shock, or prolonged brooding over real or imaginary troubles; they refuse sympathy but at the same time fancy themselves neglected by friends...The patient has a disposition to brood over sorrows, has remorse about imaginary 'crimes', is intolerant of noise and tends to fixed ideas." (Dewey)