Damiana was named "mizib-coc" (or plant for asthma) by the Maya Indians of the Yucatan, and used for pulmonary lung disorders and for treating vertigo (dizziness). It is also known to arouse sexual desire and to be a sexual rejuvenator especially when experiencing a loss of vitality in the sexual organs. For men, Damiana has been useful in increasing sperm count and helps overcome exhaustion quickly. For women, it has been useful in strengthening the reproductive organs as well as helping with the symptoms of both PMS and menopause by controlling and reducing hot flashes in the latter.

Damiana is one of the herbs of choice for helping with sexual impotency and infertility with both males and females, helping to balance the hormonal system of both sexes. It also seems to stimulate muscular contraction of the intestinal tract. Damiana is thought to be a safe stimulant of the central nervous system.