Fibrinogen, Increases With Tissue Inflammation
Fibrinogen is a soluble protein synthesized in the liver and circulates in the blood. At the time of an injury fibrinogen is converted to fibrin, which is an insoluble material that forms blood clots. A fibrinogen assay, part of the arthritis panel, measures the concentration of fibrinogen in the blood. High plasma fibrinogen concentration helps indicate future coronary heart disease in men and women. Drugs that may increase fibrinogen levels include birth control pills and estrogen.
Fibrinogen plays two important roles in our body.
- Levels increase with tissue inflammation or tissue destruction.
- It is vital part of the coagulation process
The normal range is 200-400 mg/dl (milligrams per deciliter). Several risk factors associated to low levels of fibrinogen are excessive bleeding, fainting, hematoma (blood accumulation under the skin), broken veins, and infections resulting from any little cut.
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